## hesim 0.1.0.9000

The current development version of hesim.

### Highlights

hesim now provides a general framework for integrating statistical models with economic evaluation. Users can build a decision model by specifying a model structure, which consists of a set of statistical models for disease progression, utilities, and costs. Each statistical model is used to simulate outcomes as a function of estimated parameters and input data. N-state partitioned survival models (PSMs) and individual-level continuous time state transition models (iCTSTMs) are now supported.

### API changes

• The argument sim was renamed sample in icea(), icea_pw(), and incr_effect().
• Custom functions and variables are no longer supported in icea and icea_pw().

### New features

Economic models—which combine the disease, utility, and cost models—can be constructed with the following classes:

• Psm() for PSMs
• IndivCtstm() for iCTSTMs

Disease models are constructed using the classes:

• PsmCurves() to simulate survival curves for each endpoint of interest
• IndivCtstmTrans() to simulate health state transitions with a iCTSTM

Utility and cost models are constructed with the StateVals class.

See the introduction for more details.

## hesim 0.1.0

The initial CRAN submission containing support for individualized cost-effectiveness analysis but not for model development.