Systematic literature reviews (SLRs) were used to identify relevant studies for estimating treatment effects for health state transitions and adverse events, utilities, and costs. Information on the SLR can be found in the PDF documentation and on GitHub within the docs/model-doc directory (which also contains all the figures, tables, output, and R code used to produce the PDF documentation). The tables-raw directory contains additional information on the treatment, study, and patient characteristics among the clinical trials comprising the clinical evidence base. Similarly, the slr directory contains information on the SLRs used to identify studies for estimating treatment effects, utilities, and costs.
Parameters in the IVI-NSCLC model are prefixed by params and exported as data when loading the iviNSCLC package. All code to create these parameters can be found in the data-raw directory. The Make-data.R file runs all relevant scripts. The data used for the multi-state and adverse events NMAs are stored within the data-raw directory here and here. Details of the statistical methods as well as the JAGS code used to estimate the Bayesian models are provided in the PDF documentation.