iviRA is an R package that runs the Innovation and Value Initiative’s (IVI’s) individual patient simulation model for rheumatoid arthritis (RA) (the IVI-RA model). The model simulates the costs, health outcomes, and risks associated with disease-modifying anti-rheumatic drugs (DMARDs) including conventional DMARDs (cDMARDs), biologic DMARDs (bDMARDs), and Janus kinase/signal transducers and activators of transcription (JAK/STAT) inhibitors for patients with moderate to severe rheumatoid arthritis (RA). The model is intended to help decision-makers assess the value of treatments for a population of patients with RA.


iviRA can be installed from GitHub using devtools:

# install.packages("devtools")

It can then be loaded into R:



The IVI-RA model is part of the Open Source Value Project (OSVP), a consensus-based process for the development of open-source cost-effectiveness models and other tools for value assessment of medical interventions. Learn more about how to collaborate here.

Web applications

In addition to running the model with the R package, users can run the model online with our web interfaces:

  • IVI-RA Model Interface: full control over treatment sequences, the patient population, model parameters, model structures, and the time horizon.
  • IVI-RA Value Tool: a more streamlined experience for users with less experience in decision-analytic modeling and rheumatoid arthritis.