Model inputs

treatments

Treatments

nma.acr.naive nma.das28.naive nma.haq.naive

NMA estimates

acr2das28

Change in DAS28 by 6-month ACR response

acr2sdai

Change in SDAI by 6-month ACR response

acr2cdai

Change in CDAI by 6-month ACR response

acr2haq

HAQ change by 6-month ACR response

acr2eular

ACR to EULAR Conversion

eular2haq

HAQ change by 6-month EULAR Response

haq.lprog

Linear HAQ progression rates

haq.lcgm

Latent Class Growth Model (LCGM) for HAQ progression

ttd.eular ttd.da ttd.all

Time to treatment discontinuation parameters

ttsi

Time to serious infection parameters

lifetable.female lifetable.male

US Lifetables 2011

mort.or

Mortality odds ratios by patient characteristics

mort.hr.haqdif

Mortality hazard ratio for change in HAQ score

tx.cost

Treatment costs

hosp.cost

Hospitalization costs

mgmt.cost

Cost of general management of RA

pain

Correlation between HAQ and pain

utility.mixture

Mixture model utility mapping

utility.wailoo

Wailoo (2006) utility mapping

utility.tx.attr

Treatment attributes

Patient population

sample_pop

Sample a patient population

get_input_data

Input data for simulation

Sample parameters for PSA

sample_pars

Sample parameters

sample_uniforms

Sample from uniform distributions

sample_normals

Sample from normal distributions

sample_mvnorm

Sample from a multivariate normal distribution

sample_dirichlets

Sample matrices using a Dirichlet distribution

sample_gammas

Sample from gamma distributions

sample_survpars

Sample survival parameters

sample_pars_utility_mixture

Utility mixture model parameters

Model structure

select_model_structures

Select model structures

Individual patient simulation

sim_iviRA

The IVI-RA simulation

Other useful functions

sim_dhaq6

Simulate change in HAQ at 6 months

sim_utility_mixture sim_utility_wailoo sim_qalys

Simulate utility after IPS

sim_survtime

Simulate survival time for RA patients